Wheeling, WV - Lewis landed here on September 7, 1803 on his newly built keelboat.  Visit Grave Creek Mound (one of the largest conical mounds constructed during the late Adena Period. Construction took place in successive stages from about 250-150 B.C.).

Maysville, Kentucky - Lewis must have recruited John Colter here on September 22^nd or 23^rd, 1803.  Later, in about 1808, Colter “discovered” Yellowstone Park area.
Visit the Mayville's Historic District, which is nestled along the banks of the Ohio River.  The Port of Maysville, an 1800s era river town. And just a short trip up the Buffalo Trace is the Washington Historic District; an authentic pioneer community of 1790s log cabins, shops and museums. 

Cincinnati, Ohio -Thomas Jefferson, who commissioned the expedition, asked Lewis to stop at Big Bone and collect bones of the giant mammals that were preserved in the salt lick. Visit Big Bone Lick State Park, Union, Kentucky near Cincinnati.